How to Avoid DAD?

Submit Manuscript | http://medcraveonline.com 43 amino acids. The PPP is derived from the Amyloid Precursor Protein (APP), which is “cut or cleaved by beta secretase and gamma secretase” to yield Aβ. Furthermore, the Aβ molecules can aggregate to form flexible soluble pathogenic Oligomers (https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC4598734/). The Oligomers are toxic to nerve cells with multiple toxin receptor candidates under investigation. It is now believed that certain “misfolded Oligomers” (MO) act as initiation “seeds” that are harmful and can induce other Aβ molecules to take the MO seed form, leading to a chain reaction akin to a Prion infection. The misfolded Aβ can induce tau protein to form MO seeds resulting in a vicious open loop cycle. This might be the reason why once mild dementia occurs it accelerates quickly to Alzheimer’s. These interventions might come a bit late or lightly to millions of families, nevertheless, some will benefit. However, for these interventions to have utility, not just in common sense level, we need to thoroughly understand the BMW basis. For readership convenience, to Mental Stimulation we provided “To read further Appendixes) Appendix A DNA Discovery; B: Eat Right; C: Exercise Regularly. This paper suggests noninvasive interventions to delay the onset of dementia reducing the chance for Alzheimer’s disease for all cohort groups.